One of these pictures A or B, is from Pfizer’s1 web site and one I’ve corrected for them; I’m always happy to help! See if you can spot the differences.
Spoiler alert, I’m about to reveal the answer. What’s missing is the innate immune response to a foreign protein - a non-self antigen, as pictured in Figure B and described in Caption 5. The innate immune system will kill any cell presenting the foreign protein or its fragments.
Natural killer cells (NK) and T-cells will destroy any cell transfected by mRNA-LNPs. “And that’s not all” you get the bonus of inflammation, swelling and fever. Probably not a big problem in an arm muscle but it is a very good example of BAD if it happens in a vital organ like the heart or brain for example!
Why leave this out? I’m guessing it’s because the real picture would be a dummies guide to creating potentially lethal2 autoimmune diseases, otherwise! And Caption 10 in Figure B points out that subsequent injections will invite the full suite of immune responses, all guns will be blazing, so to speak! ;-(
I'm fuzzy on the whole good/bad thing. What do you mean, "bad"?
Try to imagine all life as you know it stopping instantaneously and every molecule in your body exploding at the speed of light. Right.
That's bad. Okay. All right. Important safety tip. Thanks, Egon. - Ghostbusters (1984)
;-)
Understanding different vaccine technologies | Pfizer UK | pfizer.co.uk
Given that we now know that the LNPs are distributed to every organ of the body. The LNPs themselves are also now known to be highly inflammatory alone. The good news is, that not all “vaccine” batches contained the same amount of active ingredients!